Seattle Genetics
Research Associate II/III, Pharmaceutical Sciences
Process Sciences - Bothell, Washington
Description
Seattle Genetics is an emerging multi-product, global biotechnology company that develops and commercializes transformative therapies targeting cancer to make a meaningful difference in people’s lives. ADCETRIS® (brentuximab vedotin) uses the company’s industry-leading antibody-drug conjugate (ADC) technology and is approved for the treatment of multiple CD30-expressing lymphomas.
Beyond ADCETRIS®, the company has established a pipeline of novel targeted therapies at various stages of clinical testing, including three in ongoing or planned pivotal trials for solid tumors. Enfortumab vedotin for metastatic urothelial cancer and tisotumab vedotin for metastatic cervical cancer use our proprietary ADC technology. Tucatinib, a small molecule tyrosine kinase inhibitor, is in a pivotal trial for HER2-positive metastatic breast cancer. In addition, we are leveraging our expertise in empowered antibodies to build a portfolio of proprietary immuno-oncology agents in clinical trials targeting hematologic malignancies and solid tumors.
Summary
The Pharmaceutical Sciences group at Seattle Genetics is seeking a highly motivated research associate to support development of therapeutic antibody-drug conjugates. This person will play a critical role in the formulation and drug product process development of a novel pre-clinical ADC. The ideal candidate will have working knowledge of biologics formulation development and experience in common analytical techniques, as well as strong critical thinking skills and the ability to design, execute, and draw conclusions from experimental studies with managerial guidance. The ideal candidate should have a background in formulation development or analytical biochemistry or a related discipline, good interpersonal skills, and an ability to work effectively in intra-departmental teams to achieve program goals.
Responsibilities:
- Assist with and conduct experiments and analyze results leading to the development of robust formulations for antibody and antibody drug conjugate (ADC) drug substances and drug products.
- Execute studies including pre-formulation characterization, liquid and lyophilized formulation development, stability studies, shipping and handling studies, evaluation of material for use in toxicology and clinical settings.
- Process data and present findings to Pharmaceutical Sciences team and project teams.
- Contribute to technical reports and prepare selected technical reports.
- Assume responsibility for more sophisticated lab equipment as SME.
Requirements:
- BS or MS in pharmaceutical sciences, chemistry, biochemistry, biological sciences or a related discipline.
- Minimum of 0-2 years (MS) or 2+ years (BS) of protein formulation or analytical experience in the academic setting or biotechnology/pharmaceutical industry.
- Good problem-solving and critical thinking skills.
- Strong data and time management stills with attention to detail.
- Ability to function as a team player as well as work independently in experimental design, implementation and results interpretation.
- Excellent analytical mindset and skills including hands-on experience with chromatographic (e.g. SEC, RP, CEX) and electrophoretic (e.g. CE-SDS, iCIEF) techniques and other analytical methods.
- Strong fundamental knowledge of protein chemistry, degradation and stabilization mechanisms.
As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.
Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.
Apply:
Seattle Genetics
Seattle Genetics is an Equal Opportunity Employer
Submitted: 10/04/2019
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